New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu.

The new thiazolyl peptide antibiotic GE2270 A, isolated from Planobispora rosea strain ATCC 53773, is shown to inhibit bacterial protein biosynthesis in vitro by affecting specifically the GTP-bound form of elongation factor Tu (EF-Tu). The 'off' rate of EF-Tu.GTP is slowed down 400-fold, locking GT...

Descripción completa

Detalles Bibliográficos

Publicado en:	EMBO J
Autores principales:	Anborgh, P H, Parmeggiani, A
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 1991
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452716/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2009857/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb08009.x
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!