New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu.
The new thiazolyl peptide antibiotic GE2270 A, isolated from Planobispora rosea strain ATCC 53773, is shown to inhibit bacterial protein biosynthesis in vitro by affecting specifically the GTP-bound form of elongation factor Tu (EF-Tu). The 'off' rate of EF-Tu.GTP is slowed down 400-fold, locking GT...
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| Pubblicato in: | EMBO J |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
1991
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452716/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2009857/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb08009.x |
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