New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu.

The new thiazolyl peptide antibiotic GE2270 A, isolated from Planobispora rosea strain ATCC 53773, is shown to inhibit bacterial protein biosynthesis in vitro by affecting specifically the GTP-bound form of elongation factor Tu (EF-Tu). The 'off' rate of EF-Tu.GTP is slowed down 400-fold, locking GT...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Anborgh, P H, Parmeggiani, A
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 1991
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452716/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2009857/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb08009.x
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