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Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver
MicroRNAs (miRNAs) are important regulators and potential therapeutic targets of metabolic disease. In this study we show by in vivo administration of locked nucleic acid (LNA) inhibitors that suppression of endogenous miR-29 lowers plasma cholesterol levels by ~40%, commensurate with the effect of...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4526858/ https://ncbi.nlm.nih.gov/pubmed/26246194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12911 |
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