Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing

Pancreatic ductal adenocarcinoma (PDAC) is a genomically diverse, prevalent, and almost invariably fatal malignancy. Although conventional genetically engineered mouse models of human PDAC have been instrumental in understanding pancreatic cancer development, these models are much too labor-intensiv...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Chiou, Shin-Heng, Winters, Ian P., Wang, Jing, Naranjo, Santiago, Dudgeon, Crissy, Tamburini, Fiona B., Brady, Jennifer J., Yang, Dian, Grüner, Barbara M., Chuang, Chen-Hua, Caswell, Deborah R., Zeng, Hong, Chu, Pauline, Kim, Grace E., Carpizo, Darren R., Kim, Seung K., Winslow, Monte M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Resource/Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526740/
https://ncbi.nlm.nih.gov/pubmed/26178787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.264861.115
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