Interaction between innate immunity and Ro52-induced antibody causes Sjögren’s syndrome-like disorder in mice

OBJECTIVES: Autoantibodies reactive with Ro52 are often found in sera of Sjögren’s syndrome (SS) patients. This study was undertaken to investigate the role of Ro52-induced immune responses in pathogenesis of SS. METHODS: New Zealand Mixed (NZM) 2758 mice were immunized with Ro52 in alum adjuvant. C...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Szczerba, Barbara M., Kaplonek, Paulina, Wolska, Nina, Podsiadlowska, Anna, Rybakowska, Paulina D., Dey, Paromita, Rasmussen, Astrid, Grundahl, Kiely, Hefner, Kimberly S, Stone, Donald U, Young, Stephen, David, M. Lewis, Radfar, Lida, Scofield, R. Hal, Sivils, Kathy L, Bagavant, Harini, Deshmukh, Umesh S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526450/
https://ncbi.nlm.nih.gov/pubmed/25906316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-206297
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