Interaction between innate immunity and Ro52-induced antibody causes Sjögren’s syndrome-like disorder in mice

OBJECTIVES: Autoantibodies reactive with Ro52 are often found in sera of Sjögren’s syndrome (SS) patients. This study was undertaken to investigate the role of Ro52-induced immune responses in pathogenesis of SS. METHODS: New Zealand Mixed (NZM) 2758 mice were immunized with Ro52 in alum adjuvant. C...

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Pubblicato in:Ann Rheum Dis
Autori principali: Szczerba, Barbara M., Kaplonek, Paulina, Wolska, Nina, Podsiadlowska, Anna, Rybakowska, Paulina D., Dey, Paromita, Rasmussen, Astrid, Grundahl, Kiely, Hefner, Kimberly S, Stone, Donald U, Young, Stephen, David, M. Lewis, Radfar, Lida, Scofield, R. Hal, Sivils, Kathy L, Bagavant, Harini, Deshmukh, Umesh S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526450/
https://ncbi.nlm.nih.gov/pubmed/25906316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-206297
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