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Immune Response against the Coiled Coil Domain of Sjögren’s Syndrome Associated Autoantigen Ro52 induces salivary gland dysfunction

OBJECTIVE: The structural domains of Ro52, termed the RING, B-box, Coiled coil (CC) and B30.2/SPRY are targets of anti-Ro52 in multiple autoimmune disorders. In Sjögren’s syndrome patients, the presence of anti-Ro52 is associated with higher disease severity, and in mice, they induce salivary gland...

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Pubblicato in:Clin Exp Rheumatol
Autori principali: Sroka, Magdalena, Bagavant, Harini, Biswas, Indranil, Ballard, Abigail, Deshmukh, Umesh S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068008/
https://ncbi.nlm.nih.gov/pubmed/29465352
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