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Immune Response against the Coiled Coil Domain of Sjögren’s Syndrome Associated Autoantigen Ro52 induces salivary gland dysfunction
OBJECTIVE: The structural domains of Ro52, termed the RING, B-box, Coiled coil (CC) and B30.2/SPRY are targets of anti-Ro52 in multiple autoimmune disorders. In Sjögren’s syndrome patients, the presence of anti-Ro52 is associated with higher disease severity, and in mice, they induce salivary gland...
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| Published in: | Clin Exp Rheumatol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6068008/ https://ncbi.nlm.nih.gov/pubmed/29465352 |
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