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Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of their Complexes with Acetylpolyamine Amidohydrolase

Polyamines are essential aliphatic polycations that bind to nucleic acids and accordingly are involved in a variety of cellular processes. Polyamine function can be regulated by acetylation and deacetylation, just as histone function can be regulated by lysine acetylation and deacetylation. Acetylpo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Decroos, Christophe, Christianson, David W.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526345/
https://ncbi.nlm.nih.gov/pubmed/26200446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00536
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