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Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of their Complexes with Acetylpolyamine Amidohydrolase
Polyamines are essential aliphatic polycations that bind to nucleic acids and accordingly are involved in a variety of cellular processes. Polyamine function can be regulated by acetylation and deacetylation, just as histone function can be regulated by lysine acetylation and deacetylation. Acetylpo...
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| Publicado no: | Biochemistry |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4526345/ https://ncbi.nlm.nih.gov/pubmed/26200446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00536 |
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