Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal

Rodent lung tumors are morphologically similar to a subtype of human lung adenocarcinomas. The objective of this study was to evaluate Kras, Egfr and Tp53 mutations, which are relevant to human lung cancer, in cobalt metal dust (CMD) induced alveolar/bronchiolar tumors of B6C3F1/N mice and F344/NTac...

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Pubblicato in:Toxicol Pathol
Autori principali: Hong, Hue-Hua L., Hoenerhoff, Mark J., Ton, Thai-Vu, Herbert, Ronald A., Kissling, Grace E., Hooth, Michelle J., Behl, Mamta, Witt, Kristine L., Smith-Roe, Stephanie L., Sills, Robert C., Pandiri, Arun R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526332/
https://ncbi.nlm.nih.gov/pubmed/26059825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623315581192
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