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Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice
Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson’s disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kinase function, impacting on neuronal maintenance, ve...
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| Veröffentlicht in: | Neurobiol Dis |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4526103/ https://ncbi.nlm.nih.gov/pubmed/25836420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.031 |
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