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Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice

Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson’s disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kinase function, impacting on neuronal maintenance, ve...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Yue, M., Hinkle, K., Davies, P., Trushina, E., Fiesel, F., Christenson, T., Schroeder, A., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S., Beevers, J., Milnerwood, A., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D., Farrer, M., Melrose, H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526103/
https://ncbi.nlm.nih.gov/pubmed/25836420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.031
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