Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice

Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson’s disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kinase function, impacting on neuronal maintenance, ve...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Neurobiol Dis
मुख्य लेखकों: Yue, M., Hinkle, K., Davies, P., Trushina, E., Fiesel, F., Christenson, T., Schroeder, A., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S., Beevers, J., Milnerwood, A., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D., Farrer, M., Melrose, H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526103/
https://ncbi.nlm.nih.gov/pubmed/25836420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.02.031
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