Selective overexpression of Toll-like receptor-4 in skeletal muscle impairs metabolic adaptation to high-fat feeding

Toll-like receptor-4 (TLR-4) is elevated in skeletal muscle of obese humans, and data from our laboratory have shown that activation of TLR-4 in skeletal muscle via LPS results in decreased fatty acid oxidation (FAO). The purpose of this study was to determine whether overexpression of TLR-4 in skel...

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Bibliografiska uppgifter
I publikationen:Am J Physiol Regul Integr Comp Physiol
Huvudupphovsmän: McMillan, Ryan P., Wu, Yaru, Voelker, Kevin, Fundaro, Gabrielle, Kavanaugh, John, Stevens, Joseph R., Shabrokh, Elika, Ali, Mostafa, Harvey, Mordecai, Anderson, Angela S., Boutagy, Nabil E., Mynatt, Randall L., Frisard, Madlyn I., Hulver, Matthew W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2015
Ämnen:
Obesity, Diabetes and Energy Homeostasis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525328/
https://ncbi.nlm.nih.gov/pubmed/26084695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00139.2015
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