Selective overexpression of Toll-like receptor-4 in skeletal muscle impairs metabolic adaptation to high-fat feeding

Toll-like receptor-4 (TLR-4) is elevated in skeletal muscle of obese humans, and data from our laboratory have shown that activation of TLR-4 in skeletal muscle via LPS results in decreased fatty acid oxidation (FAO). The purpose of this study was to determine whether overexpression of TLR-4 in skel...

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Detalhes bibliográficos
Publicado no:Am J Physiol Regul Integr Comp Physiol
Main Authors: McMillan, Ryan P., Wu, Yaru, Voelker, Kevin, Fundaro, Gabrielle, Kavanaugh, John, Stevens, Joseph R., Shabrokh, Elika, Ali, Mostafa, Harvey, Mordecai, Anderson, Angela S., Boutagy, Nabil E., Mynatt, Randall L., Frisard, Madlyn I., Hulver, Matthew W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Obesity, Diabetes and Energy Homeostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525328/
https://ncbi.nlm.nih.gov/pubmed/26084695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00139.2015
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