Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation

Chromosome condensation is a hallmark of mitosis in eukaryotes and is a prerequisite for faithful segregation of genetic material to daughter cells. Here we show that condensin, which is essential for assembling condensed chromosomes, helps to preclude the detrimental effects of gene transcription o...

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Udgivet i:Nat Commun
Main Authors: Sutani, Takashi, Sakata, Toyonori, Nakato, Ryuichiro, Masuda, Koji, Ishibashi, Mai, Yamashita, Daisuke, Suzuki, Yutaka, Hirano, Tatsuya, Bando, Masashige, Shirahige, Katsuhiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525155/
https://ncbi.nlm.nih.gov/pubmed/26204128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8815
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