Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion

Metaplastic epithelial cells of Barrett's esophagus transformed by the combination of p53-knockdown and oncogenic Ras expression are known to activate signal transducer and activator of transcription 3 (STAT3). When phosphorylated at tyrosine 705 (Tyr705), STAT3 functions as a nuclear transcrip...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Yu, Chunhua, Huo, Xiaofang, Agoston, Agoston T., Zhang, Xi, Theiss, Arianne L., Cheng, Edaire, Zhang, Qiuyang, Zaika, Alexander, Pham, Thai H., Wang, David H., Lobie, Peter E., Odze, Robert D., Spechler, Stuart J., Souza, Rhonda F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525109/
https://ncbi.nlm.nih.gov/pubmed/26045618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00462.2014
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