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Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion

Metaplastic epithelial cells of Barrett's esophagus transformed by the combination of p53-knockdown and oncogenic Ras expression are known to activate signal transducer and activator of transcription 3 (STAT3). When phosphorylated at tyrosine 705 (Tyr705), STAT3 functions as a nuclear transcrip...

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Veröffentlicht in:Am J Physiol Gastrointest Liver Physiol
Hauptverfasser: Yu, Chunhua, Huo, Xiaofang, Agoston, Agoston T., Zhang, Xi, Theiss, Arianne L., Cheng, Edaire, Zhang, Qiuyang, Zaika, Alexander, Pham, Thai H., Wang, David H., Lobie, Peter E., Odze, Robert D., Spechler, Stuart J., Souza, Rhonda F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4525109/
https://ncbi.nlm.nih.gov/pubmed/26045618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00462.2014
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