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The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.
The protein tyrosine phosphatase CD45 is a critical component of the T cell antigen receptor (TCR) signaling pathway, acting as a positive regulator of Src family protein tyrosine kinases (PTKs) such as Lck. Most CD45-deficient human and murine T cell lines are unable to signal through their TCRs. H...
Sparad:
| I publikationen: | EMBO J |
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| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
1996
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8947048/ |
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