The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.

The protein tyrosine phosphatase CD45 is a critical component of the T cell antigen receptor (TCR) signaling pathway, acting as a positive regulator of Src family protein tyrosine kinases (PTKs) such as Lck. Most CD45-deficient human and murine T cell lines are unable to signal through their TCRs. H...

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Bibliografiska uppgifter
I publikationen:EMBO J
Huvudupphovsmän: Chu, D H, Spits, H, Peyron, J F, Rowley, R B, Bolen, J B, Weiss, A
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 1996
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452448/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8947048/
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