Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation

DNA double-strand breaks (DSBs) are involved in many cellular mechanisms, including replication, transcription, and genome rearrangements. The recent observation that hot spots of DSBs in human chromosomes delimit DNA domains that possess coordinately expressed genes suggests a strong relationship b...

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Veröffentlicht in:J Mol Cell Biol
Hauptverfasser: Tchurikov, Nickolai A., Fedoseeva, Daria M., Sosin, Dmitri V., Snezhkina, Anastasia V., Melnikova, Nataliya V., Kudryavtseva, Anna V., Kravatsky, Yuri V., Kretova, Olga V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524424/
https://ncbi.nlm.nih.gov/pubmed/25280477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mju038
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