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Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity

Influenza A virus PA-X comprises an N-terminal PA endonuclease domain and a C-terminal PA-X-specific domain. PA-X reduces host and viral mRNA accumulation via its endonuclease function. Here, we found that the N-terminal 15 amino acids, particularly six basic amino acids, in the C-terminal PA-X-spec...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Oishi, Kohei, Yamayoshi, Seiya, Kawaoka, Yoshihiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524237/
https://ncbi.nlm.nih.gov/pubmed/26041295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01132-15
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