Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro

BACKGROUND: Autophagy is a conserved cellular self-digestion mechanism that can either suppress or promote cancer in a context-dependent manner. In ovarian cancer, prevalent mono-allelic deletion of BECN1 (a canonical autophagy-inducer) suggests that autophagy is impaired to promote carcinogenesis a...

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Podrobná bibliografie
Vydáno v:J Ovarian Res
Hlavní autoři: Correa, Rohann J. M., Valdes, Yudith Ramos, Shepherd, Trevor G., DiMattia, Gabriel E.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524172/
https://ncbi.nlm.nih.gov/pubmed/26239434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13048-015-0182-y
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