Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability

Recent genomics analysis of the high-grade serous subtype of epithelial ovarian cancer (EOC) show aberrations in the phosphatidylinositol 3-kinase (PI3K)/AKT pathway that result in upregulated signaling activity. Thus, the PI3K/AKT pathway represents a potential therapeutic target for aggressive hig...

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Autors principals: Correa, Rohann J.M., Valdes, Yudith Ramos, Peart, Teresa M., Fazio, Elena N., Bertrand, Monique, McGee, Jacob, Préfontaine, Michel, Sugimoto, Akira, DiMattia, Gabriel E., Shepherd, Trevor G.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Original Manuscript
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146408/
https://ncbi.nlm.nih.gov/pubmed/24562574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu049
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