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Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro
BACKGROUND: Autophagy is a conserved cellular self-digestion mechanism that can either suppress or promote cancer in a context-dependent manner. In ovarian cancer, prevalent mono-allelic deletion of BECN1 (a canonical autophagy-inducer) suggests that autophagy is impaired to promote carcinogenesis a...
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| Publié dans: | J Ovarian Res |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4524172/ https://ncbi.nlm.nih.gov/pubmed/26239434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13048-015-0182-y |
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