Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Bukh, Jens, Engle, Ronald E., Faulk, Kristina, Wang, Richard Y., Farci, Patrizia, Alter, Harvey J., Purcell, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524056/
https://ncbi.nlm.nih.gov/pubmed/26085160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01194-15
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