Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Bukh, Jens, Engle, Ronald E., Faulk, Kristina, Wang, Richard Y., Farci, Patrizia, Alter, Harvey J., Purcell, Robert H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524056/
https://ncbi.nlm.nih.gov/pubmed/26085160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01194-15
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