Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Bukh, Jens, Engle, Ronald E., Faulk, Kristina, Wang, Richard Y., Farci, Patrizia, Alter, Harvey J., Purcell, Robert H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2015
Konular:
Pathogenesis and Immunity
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524056/
https://ncbi.nlm.nih.gov/pubmed/26085160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01194-15
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