CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2

Nrf2 is the pre-dominant transcription activator responsible for coordinated up-regulation of ARE-driven antioxidant and detoxification genes. The activity of Nrf2 is tightly regulated at basal levels through its ubiquitination by Cul3-Keap1 and consequential degradation. Upon exposure to stress, th...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Kigoshi, Yu, Fukuda, Tomomi, Endo, Tomoyuki, Hayasaka, Nami, Iemura, Shun-ichiro, Natsume, Toru, Tsuruta, Fuminori, Chiba, Tomoki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523873/
https://ncbi.nlm.nih.gov/pubmed/26238671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12857
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