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CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2
Nrf2 is the pre-dominant transcription activator responsible for coordinated up-regulation of ARE-driven antioxidant and detoxification genes. The activity of Nrf2 is tightly regulated at basal levels through its ubiquitination by Cul3-Keap1 and consequential degradation. Upon exposure to stress, th...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4523873/ https://ncbi.nlm.nih.gov/pubmed/26238671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12857 |
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