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Real-time imaging of bHLH transcription factors reveals their dynamic control in the multipotency and fate choice of neural stem cells

The basic-helix-loop-helix (bHLH) transcription factors Ascl1/Mash1, Hes1, and Olig2 regulate the fate choice of neurons, astrocytes, and oligodendrocytes, respectively; however, these factors are coexpressed in self-renewing multipotent neural stem cells (NSCs) even before cell fate determination....

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Publicat a:Front Cell Neurosci
Autors principals: Imayoshi, Itaru, Ishidate, Fumiyoshi, Kageyama, Ryoichiro
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523821/
https://ncbi.nlm.nih.gov/pubmed/26300726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00288
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