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Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock

Hes7, a bHLH gene essential for somitogenesis, displays cyclic expression of mRNA in the presomitic mesoderm (PSM). Here, we show that Hes7 protein is also expressed in a dynamic manner, which depends on proteasome-mediated degradation. Spatial comparison revealed that Hes7 and Lunatic fringe (Lfng)...

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Main Authors: Bessho, Yasumasa, Hirata, Hiromi, Masamizu, Yoshito, Kageyama, Ryoichiro
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2003
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC196074/
https://ncbi.nlm.nih.gov/pubmed/12783854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1092303
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