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Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock
Hes7, a bHLH gene essential for somitogenesis, displays cyclic expression of mRNA in the presomitic mesoderm (PSM). Here, we show that Hes7 protein is also expressed in a dynamic manner, which depends on proteasome-mediated degradation. Spatial comparison revealed that Hes7 and Lunatic fringe (Lfng)...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196074/ https://ncbi.nlm.nih.gov/pubmed/12783854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1092303 |
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