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A lifelong exposure to a Western-style diet, but not aging, alters global DNA methylation in mouse colon

BACKGROUND/OBJECTIVES: Previous studies have indicated that when compared to young mice, old mice have lower global DNA methylation and higher p16 promoter methylation in colonic mucosa, which is a common finding in colon cancer. It is also known that a Western-style diet (WSD) high in fat and calor...

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Détails bibliographiques
Publié dans:Nutr Res Pract
Auteurs principaux: Choi, Sang-Woon, Tammen, Stephanie A, Liu, Zhenhua, Friso, Simonetta
Format: Artigo
Langue:Inglês
Publié: The Korean Nutrition Society and the Korean Society of Community Nutrition 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523478/
https://ncbi.nlm.nih.gov/pubmed/26244073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4162/nrp.2015.9.4.358
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