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Aging Alters Hepatic DNA Hydroxymethylation, as Measured by Liquid Chromatography/Mass Spectrometry

BACKGROUND: Aging is one of the most important risk factors for cancer. It appears that aberrant epigenetic changes might be a common driver of aging and cancer. Among them are changes in DNA methylation and DNA hydroxymethylation. The 5′ carbon of cytosines in CpG dinucleotides of DNA can be either...

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Vydáno v:J Cancer Prev
Hlavní autoři: Tammen, Stephanie A., Dolnikowski, Gregory G., Ausman, Lynne M., Liu, Zhenhua, Kim, Kyong-chol, Friso, Simonetta, Choi, Sang-Woon
Médium: Artigo
Jazyk:Inglês
Vydáno: Korean Society of Cancer Prevention 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285961/
https://ncbi.nlm.nih.gov/pubmed/25574465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15430/JCP.2014.19.4.301
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