Targeting MYCN IRES in MYCN‐amplified neuroblastoma with miR‐375 inhibits tumor growth and sensitizes tumor cells to radiation

The MYCN oncogene is amplified in 20% of neuroblastomas, leading to its overexpression at both the mRNA and protein levels. MYCN overexpression is strongly associated with advanced disease stage, rapid tumor progression and a worse prognosis. In the present study, we identified microRNA‐375 (miR‐375...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Zhang, Hailong, Liu, Tao, Yi, Sha, Gu, Lubing, Zhou, Muxiang
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523463/
https://ncbi.nlm.nih.gov/pubmed/25864587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.03.005
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