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Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma

Previous studies show that the MYCN and MDM2-p53 signal pathways are mutually regulated: MYCN stimulates MDM2 and p53 transcription, whereas MDM2 stabilizes MYCN mRNA and induces its translation. Herein, we report that the interaction between MDM2 and MYCN plays a critical role in MYCN-amplified neu...

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Detalhes bibliográficos
Main Authors: He, Jing, Gu, Lubing, Zhang, Hailong, Zhou, Muxiang
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218600/
https://ncbi.nlm.nih.gov/pubmed/21862876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.17.17118
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