Instability of a dinucleotide repeat in the 3′‐untranslated region (UTR) of the microsomal prostaglandin E synthase‐1 (mPGES‐1) gene in microsatellite instability‐high (MSI‐H) colorectal carcinoma

DNA mismatch‐repair gene mutations, with consequent loss of functional protein expression, result in microsatellite instability (MSI). Microsatellite sequences are found in coding regions and in regulatory regions of genes (i.e., 5′‐UTRs and 3′‐UTRs). In addition to being a surrogate marker of defec...

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Bibliografske podrobnosti
izdano v:Mol Oncol
Main Authors: Cherukuri, Durga Prasad, Deignan, Joshua L., Das, Kingshuk, Grody, Wayne W., Herschman, Harvey
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523444/
https://ncbi.nlm.nih.gov/pubmed/25817443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.01.009
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