Instability of a dinucleotide repeat in the 3′‐untranslated region (UTR) of the microsomal prostaglandin E synthase‐1 (mPGES‐1) gene in microsatellite instability‐high (MSI‐H) colorectal carcinoma

DNA mismatch‐repair gene mutations, with consequent loss of functional protein expression, result in microsatellite instability (MSI). Microsatellite sequences are found in coding regions and in regulatory regions of genes (i.e., 5′‐UTRs and 3′‐UTRs). In addition to being a surrogate marker of defec...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Cherukuri, Durga Prasad, Deignan, Joshua L., Das, Kingshuk, Grody, Wayne W., Herschman, Harvey
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523444/
https://ncbi.nlm.nih.gov/pubmed/25817443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.01.009
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