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Synthesis of Norbornane Bisether Antibiotics via Silver-mediated Alkylation

A small series of norbornane bisether diguanidines have been synthesized and evaluated as antibacterial agents. The key transformation—bisalkylation of norbornane diol 6—was not successful using Williamson methodology but has been accomplished using Ag(2)O mediated alkylation. Further functionalizat...

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Detalhes bibliográficos
Publicado no:RSC Adv
Main Authors: Hickey, Shane M., Ashton, Trent D., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A., Pfeffer, Frederick M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523246/
https://ncbi.nlm.nih.gov/pubmed/26251697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5RA03321G
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