Synthesis of Norbornane Bisether Antibiotics via Silver-mediated Alkylation

A small series of norbornane bisether diguanidines have been synthesized and evaluated as antibacterial agents. The key transformation—bisalkylation of norbornane diol 6—was not successful using Williamson methodology but has been accomplished using Ag(2)O mediated alkylation. Further functionalizat...

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Publicat a:RSC Adv
Autors principals: Hickey, Shane M., Ashton, Trent D., White, Jonathan M., Li, Jian, Nation, Roger L., Yu, Heidi Y., Elliott, Alysha G., Butler, Mark S., Huang, Johnny X., Cooper, Matthew A., Pfeffer, Frederick M.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523246/
https://ncbi.nlm.nih.gov/pubmed/26251697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5RA03321G
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