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Norbornane-based Cationic Antimicrobial Peptidomimetics Targeting the Bacterial Membrane

The design, synthesis and evaluation of a small series of potent amphiphilic norbornane antibacterial agents has been performed (compound 10 MIC = 0.25 μg/mL against MRSA). Molecular modelling indicates rapid aggregation of this class of antibacterial agent prior to membrane association and insertio...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Hickey, Shane M., Ashton, Trent D., Boer, Gareth, Bader, Christie A., Thomas, Michael, Elliott, Alysha G., Schmuck, Carsten, Yu, Heidi Y., Li, Jian, Nation, Roger L., Cooper, Matthew A., Plush, Sally E., Brooks, Douglas A., Pfeffer, Frederick M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309908/
https://ncbi.nlm.nih.gov/pubmed/30316060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.09.072
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