Norbornane-based Cationic Antimicrobial Peptidomimetics Targeting the Bacterial Membrane

The design, synthesis and evaluation of a small series of potent amphiphilic norbornane antibacterial agents has been performed (compound 10 MIC = 0.25 μg/mL against MRSA). Molecular modelling indicates rapid aggregation of this class of antibacterial agent prior to membrane association and insertio...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Eur J Med Chem
Hlavní autoři: Hickey, Shane M., Ashton, Trent D., Boer, Gareth, Bader, Christie A., Thomas, Michael, Elliott, Alysha G., Schmuck, Carsten, Yu, Heidi Y., Li, Jian, Nation, Roger L., Cooper, Matthew A., Plush, Sally E., Brooks, Douglas A., Pfeffer, Frederick M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309908/
https://ncbi.nlm.nih.gov/pubmed/30316060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.09.072
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky