Rsu1 regulates ethanol consumption in Drosophila and humans

Alcohol abuse is highly prevalent, but little is understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We show that Rsu1 is required in the adu...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ojelade, Shamsideen A., Jia, Tianye, Rodan, Aylin R., Chenyang, Tao, Kadrmas, Julie L., Cattrell, Anna, Ruggeri, Barbara, Charoen, Pimphen, Lemaitre, Hervé, Banaschewski, Tobias, Büchel, Christian, Bokde, Arun L. W., Carvalho, Fabiana, Conrod, Patricia J., Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny A., Heinz, Andreas, Ittermann, Bernd, Lathrop, Mark, Lubbe, Steven, Martinot, Jean-Luc, Paus, Tomás, Smolka, Michael N., Spanagel, Rainer, O’Reilly, Paul F., Laitinen, Jaana, Veijola, Juha M., Feng, Jianfeng, Desrivières, Sylvane, Jarvelin, Marjo-Riitta, Schumann, Gunter, Rothenfluh, Adrian
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522778/
https://ncbi.nlm.nih.gov/pubmed/26170296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417222112
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