Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here we investigate the biological basis of this obse...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Child Psychol Psychiatry
Prif Awduron: Ruggeri, Barbara, Macare, Christine, Stopponi, Serena, Jia, Tianye, Carvalho, Fabiana M., Robert, Gabriel, Banaschewski, Tobias, Bokde, Arun LW, Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean Luc, Paillère Martinot, Marie-Laure, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N, Vetter, Nora C., Walter, Henrik, Whelan, Robert, Sommer, Wolfgang H, Bakalkin, Georgy, Ciccocioppo, Roberto, Schumann, Gunter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975104/
https://ncbi.nlm.nih.gov/pubmed/29197086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcpp.12843
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