Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here we investigate the biological basis of this obse...

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Publicado no:J Child Psychol Psychiatry
Main Authors: Ruggeri, Barbara, Macare, Christine, Stopponi, Serena, Jia, Tianye, Carvalho, Fabiana M., Robert, Gabriel, Banaschewski, Tobias, Bokde, Arun LW, Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean Luc, Paillère Martinot, Marie-Laure, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N, Vetter, Nora C., Walter, Henrik, Whelan, Robert, Sommer, Wolfgang H, Bakalkin, Georgy, Ciccocioppo, Roberto, Schumann, Gunter
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975104/
https://ncbi.nlm.nih.gov/pubmed/29197086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcpp.12843
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