Rsu1 regulates ethanol consumption in Drosophila and humans

Alcohol abuse is highly prevalent, but little is understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We show that Rsu1 is required in the adu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ojelade, Shamsideen A., Jia, Tianye, Rodan, Aylin R., Chenyang, Tao, Kadrmas, Julie L., Cattrell, Anna, Ruggeri, Barbara, Charoen, Pimphen, Lemaitre, Hervé, Banaschewski, Tobias, Büchel, Christian, Bokde, Arun L. W., Carvalho, Fabiana, Conrod, Patricia J., Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny A., Heinz, Andreas, Ittermann, Bernd, Lathrop, Mark, Lubbe, Steven, Martinot, Jean-Luc, Paus, Tomás, Smolka, Michael N., Spanagel, Rainer, O’Reilly, Paul F., Laitinen, Jaana, Veijola, Juha M., Feng, Jianfeng, Desrivières, Sylvane, Jarvelin, Marjo-Riitta, Schumann, Gunter, Rothenfluh, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522778/
https://ncbi.nlm.nih.gov/pubmed/26170296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417222112
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