Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13

Proteases play important roles in many biologic processes and are key mediators of cancer, inflammation, and thrombosis. However, comprehensive and quantitative techniques to define the substrate specificity profile of proteases are lacking. The metalloprotease ADAMTS13 regulates blood coagulation b...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Kretz, Colin A., Dai, Manhong, Soylemez, Onuralp, Yee, Andrew, Desch, Karl C., Siemieniak, David, Tomberg, Kärt, Kondrashov, Fyodor A., Meng, Fan, Ginsburg, David
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522773/
https://ncbi.nlm.nih.gov/pubmed/26170332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511328112
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