Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20

Lignende værker

• Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PR(S17)
  af: Agniswamy, Johnson, et al.
  Udgivet: (2021)
• Design, Synthesis, and X-ray Structure of Substituted Bis-tetrahydrofuran (Bis-THF)-Derived Potent HIV-1 Protease Inhibitors
  af: Ghosh, Arun K., et al.
  Udgivet: (2011)
• Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20
  af: Kneller, Daniel W., et al.
  Udgivet: (2019)
• Design of Gem-difluoro-bis-Tetrahydrofuran as P2-Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation
  af: Ghosh, Arun K., et al.
  Udgivet: (2014)
• Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1′-pyrrolidinone or P2-tris-tetrahydrofuran
  af: Agniswamy, Johnson, et al.
  Udgivet: (2013)