Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20

An extremely drug resistant mutant of HIV-1 protease (PR) bearing 20 mutations (PR20) has been studied with two potent antiviral investigational inhibitors. GRL-5010A and GRL-4410A were designed to introduce hydrogen bond interactions with the flexible flaps of the PR by incorporating gem-difluorine...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Agniswamy, Johnson, Louis, John M., Shen, Chen-Hsiang, Yashchuk, Sofiya, Ghosh, Arun K., Weber, Irene T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522690/
https://ncbi.nlm.nih.gov/pubmed/26010498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00474
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