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Docking and Migration of Carbon Monoxide in Nitrogenase: The Case for Gated Pockets from IR Spectroscopy and Molecular Dynamics

Evidence for a CO docking site near the FeMo-cofactor in nitrogenase has been obtained by FT-IR monitored low temperature photolysis. We investigated the possible migration paths for CO from this docking site using molecular dynamics calculations. The simulations support the notion of a gas channel...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Gee, Leland B., Leontyev, Igor, Stuchebrukhov, Alexei, Scott, Aubrey D., Pelmenschikov, Vladimir, Cramer, Stephen P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522414/
https://ncbi.nlm.nih.gov/pubmed/25919807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00216
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