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Synthesis and Evaluation of Bile acid-ribavirin Conjugates as Prodrugs to Target the Liver
Ribavirin is used to treat hepatitis C but causes serious hemolytic anemia. The objective of the study was to develop a ribavirin prodrug to achieve liver specific drug delivery and to reduce its off-target effect in red blood cells (RBC). The approach aimed to target the human sodium taurocholate c...
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| Pubblicato in: | J Pharm Sci |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4522399/ https://ncbi.nlm.nih.gov/pubmed/25645375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24375 |
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