Genome-wide Association Study of Tenofovir Pharmacokinetics and Creatinine Clearance in AIDS Clinical Trials Group Protocol A5202

BACKGROUND: Tenofovir disoproxil fumarate (TDF) causes kidney toxicity in some patients. We performed genome-wide analyses to identify associations with plasma tenofovir clearance and change in creatinine clearance (CrCl) during the first 6 months after initiating therapy among subjects randomized t...

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Veröffentlicht in:Pharmacogenet Genomics
Hauptverfasser: Wanga, Valentine, Venuto, Charles, Morse, Gene D., Acosta, Edward P., Daar, Eric S., Haas, David W., Li, Chun, Shepherd, Bryan E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522226/
https://ncbi.nlm.nih.gov/pubmed/26148204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000156
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