Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants

OBJECTIVES: Prior candidate gene studies have associated CYP2B6 516G→T [rs3745274] and 983T→C [rs28399499] with increased plasma efavirenz exposure. We sought to identify novel variants associated with efavirenz pharmacokinetics. MATERIALS AND METHODS: Antiretroviral therapy-naive AIDS Clinical Tria...

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Main Authors: Holzinger, Emily R., Grady, Benjamin, Ritchie, Marylyn D., Ribaudo, Heather J., Acosta, Edward P., Morse, Gene D., Gulick, Roy M., Robbins, Gregory K., Clifford, David B., Daar, Eric S., McLaren, Paul, Haas, David W.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3614365/
https://ncbi.nlm.nih.gov/pubmed/23080225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835a450b
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