Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants

OBJECTIVES: Prior candidate gene studies have associated CYP2B6 516G→T [rs3745274] and 983T→C [rs28399499] with increased plasma efavirenz exposure. We sought to identify novel variants associated with efavirenz pharmacokinetics. MATERIALS AND METHODS: Antiretroviral therapy-naive AIDS Clinical Tria...

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主要な著者: Holzinger, Emily R., Grady, Benjamin, Ritchie, Marylyn D., Ribaudo, Heather J., Acosta, Edward P., Morse, Gene D., Gulick, Roy M., Robbins, Gregory K., Clifford, David B., Daar, Eric S., McLaren, Paul, Haas, David W.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3614365/
https://ncbi.nlm.nih.gov/pubmed/23080225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835a450b
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