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Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts

RATIONALE: The role of Parkin in hearts is unclear. Germ-line Parkin knockout mice have normal hearts, but Parkin is protective in cardiac ischemia. Parkin-mediated mitophagy is reportedly either irrelevant, or a major factor, in the lethal cardiomyopathy evoked by cardiac myocyte-specific interrupt...

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Bibliografische gegevens
Gepubliceerd in:Circ Res
Hoofdauteurs: Song, Moshi, Gong, Guohua, Burelle, Yan, Gustafsson, Asa B., Kitsis, Richard N., Matkovich, Scot J., Dorn, Gerald W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522211/
https://ncbi.nlm.nih.gov/pubmed/26038571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.306859
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