Effect of Osmotic Pressure on the Stability of Whole Inactivated Influenza Vaccine for Coating on Microneedles

Enveloped virus vaccines can be damaged by high osmotic strength solutions, such as those used to protect the vaccine antigen during drying, which contain high concentrations of sugars. We therefore studied shrinkage and activity loss of whole inactivated influenza virus in hyperosmotic solutions an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Choi, Hyo-Jick, Song, Jae-Min, Bondy, Brian J., Compans, Richard W., Kang, Sang-Moo, Prausnitz, Mark R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521748/
https://ncbi.nlm.nih.gov/pubmed/26230936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134431
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