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Effect of Osmotic Pressure on the Stability of Whole Inactivated Influenza Vaccine for Coating on Microneedles

Enveloped virus vaccines can be damaged by high osmotic strength solutions, such as those used to protect the vaccine antigen during drying, which contain high concentrations of sugars. We therefore studied shrinkage and activity loss of whole inactivated influenza virus in hyperosmotic solutions an...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Choi, Hyo-Jick, Song, Jae-Min, Bondy, Brian J., Compans, Richard W., Kang, Sang-Moo, Prausnitz, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521748/
https://ncbi.nlm.nih.gov/pubmed/26230936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134431
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