Effect of Osmotic Pressure on the Stability of Whole Inactivated Influenza Vaccine for Coating on Microneedles

Enveloped virus vaccines can be damaged by high osmotic strength solutions, such as those used to protect the vaccine antigen during drying, which contain high concentrations of sugars. We therefore studied shrinkage and activity loss of whole inactivated influenza virus in hyperosmotic solutions an...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Choi, Hyo-Jick, Song, Jae-Min, Bondy, Brian J., Compans, Richard W., Kang, Sang-Moo, Prausnitz, Mark R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521748/
https://ncbi.nlm.nih.gov/pubmed/26230936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134431
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